The antimicrobial effectiveness test demonstrates that the effectiveness of the preservative system in a product. A product is inoculated with a controlled quantity of specific microorganism then compares the level of microorganisms found on a control sample vs. test sample over a period of 28 day. Antimicrobial preservatives are the substances added to the non sterile dosage form to protect them from microbial growth or from micro organism that are introduced in advertently during or subsequent manufacturing process. All antimicrobial substances are toxic in nature when given to the patient for maximum protection. So, concentration of preservative should be below the toxic level to the human beings. It’s necessary to check the concentration of preservatives in a dosage form through various methods to maintain the quality products.
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